This brief builds on previous findings and on our previous work showing that the challenges, opportunities, and lived experiences of Latinx individuals vary significantly by their nativity status—a term used to distinguish people who were born in the United States from those who were born outside it—and that these differences are tied in significant ways to their and their children’s well-being. These differences should be considered when examining how policies and programs support the diverse needs of Latino individuals. The brief has three main parts. First, we describe theoretical perspectives that support a disaggregated approach—that is, examining different Latino subgroups separately—to understanding Latino individuals’ well-being by considering their nativity status. Second, we use a strength-based approach to summarize existing research on how Latino families vary by nativity status in their family processes (i.e., co-parenting and parenting), psychological functioning (i.e., mental health), stressors (e.g., poverty), promotive factors (factors such as optimism and bicultural identity that are related to positive outcomes), protective factors (factors that might mitigate the negative effects of risks on outcomes), and children’s well-being. Third, we discuss implications of our findings and review important policy and program considerations. (author abstract)