The Nurse-Family Partnership (NFP) is a program of prenatal and infancy home visiting by nurses for low-income first-time mothers. NFP nurses help parents improve 1) the outcomes of pregnancy by helping women improve their prenatal health; 2) children's subsequent health and development by helping parents provide competent infant and toddler care; and 3) parents' economic self-sufficiency by helping them complete their educations, find work, and plan future pregnancies. In three scientifically controlled trials the program produced benefits in each of these targeted areas. Today the NFP is serving over 20,000 families, and is likely to grow substantially with the support of health care reform. (author abstract)