In 2021, the Office of Planning, Research, and Evaluation in the Administration for Children and Families, U.S. Department of Health and Human Services, contracted with Mathematica to design and conduct the 2021–2022 Study of Family and Staff Well-Being in Head Start Family and Child Experiences Survey Programs (the 2021–2022 Study). The 2021–2022 Study builds on the Head Start Family and Child Experiences Survey (FACES). This report includes information on the 2021–2022 Study design and presents key findings from the study’s fall 2021 data collection. (author abstract)