The National Household Education Surveys Program of 2019 (NHES:2019) Data File User’s Manual provides documentation and guidance for users of the NHES:2019 data files. The manual provides information about the purpose of the study, the sample design, the data collection procedures, the data processing procedures, response rates, imputation, weighting and standard error calculation and use, the data files and codebooks, data considerations and anomalies, and derived variable details. In addition, the manual contains a nonresponse bias analysis, comparisons of estimates from NHES:2019 to those from prior NHES administrations and other data sources, tables of nonresponse adjustment cells and response rates, copies of the data collection instruments, and the data file layouts for the public and restricted-use data files. (author abstract)