In this chapter, we present a framework with suggested measures and indicators for gauging the success of two-generation strategies emerging under what is now being referred to as "Two-Generation 2.0" (Chase-Lansdale & Brooks-Gunn, 2014). We build on research in the emerging two-generation field, including important work supported by Ascend at the Aspen Institute, the Foundation for Child Development, the Annie E. Casey and W.K. Kellogg foundations, and the U.S. Department of Health and Human Services' (USHHS) Administration for Children and Families (ACF) and Office of Planning, Research and Evaluation (OPRE), among others. (author abstract)