The Patient Protection and Affordable Care Act, signed into law in 2010, established a new program designed to improve outcomes for at-risk pregnant women and mothers and children from birth through age 5: the Maternal, Infant, and Early Childhood Home Visiting Program (MIECHV). MIECHV offers funding to states and territories to provide home visiting services. Three percent of MIECHV funds must be set aside for grants to federally recognized tribes, tribal organizations, or urban American Indian organizations. The act requires that 75 percent of grantees' funds must be used for home visiting program models with evidence of effectiveness based on rigorous evaluation research. As a result of this requirement, the Administration for Children and Families (ACF), Office of Planning, Research, and Evaluation (OPRE), part of the U.S. Department of Health and Human Services (DHHS), in collaboration with the Health Resources and Services Administration, contracted with Mathematica Policy Research to conduct a systematic review of home visiting research. Mathematica conducted the review under the guidance of a DHHS interagency working group. This review, known as the Home Visiting Evidence of Effectiveness (HomVEE) project, determines which home visiting program models have sufficient evidence to meet the DHHS criteria for an "evidence-based early childhood home visiting service delivery model." States, territories, and tribes direct the majority of their funding to support implementation of these program models. The HomVEE review only includes program models that use home visiting as the primary mode of service delivery and aim to improve outcomes in at least one of the eight domains specified in the legislation. These domains are (1) maternal health; (2) child health; (3) positive parenting practices; (4) child development and school readiness; (5) reductions in child maltreatment; (6) family economic self-sufficiency; (7) linkages and referrals to community resources and supports; and (8) reductions in juvenile delinquency, family violence, and crime. (author abstract)