This paper is intended to serve as a getting-started guide for state and local policymakers as they begin to develop and implement two-generation strategies in their areas. It begins with an overview of the most recent family of innovative two-generation programs and provides several examples of the model that illustrate different approaches to a two-generation strategy with strong workforce and/or education components. While the programs are by no means identical, each has developed a coordinated array of services to address the needs of low-income families and improve their educational and economic outcomes over time. The guide presents five facilitating factors that appear to be linked to the success of two-generation strategies: supportive policy frameworks; leadership; program administration; integrated and flexible funding streams; and evidence-oriented culture. The guide then details some of the common steps taken in establishing two-generation programs, and identifies recommendations for state and local policymakers interested in implementing a two-generation approach. (author abstract)