For each state and territory, we present a four-page profile organized around four themes: Covid-19 Impacts, Race and Ethnicity, Gender, and State Variation. Most data on the profile pages come from the 2020-2021 school year (typically Fall 2020), unless otherwise noted. To facilitate comparisons, national averages are reported with each state profile. National averages are based on the 50 States, D.C., and the U.S. territories. In most places, percentages are displayed as whole numbers while the figures reflect the more precise underlying values. (author abstract)