AIAN FACES 2019 is the second round of this national study in Region XI Head Start. Mathematica and its partner, Educational Testing Service, conducted the study for the Office of Planning, Research, and Evaluation, Administration for Children and Families, U.S. Department of Health and Human Services. The tables in this report describe the children enrolled in Region XI Head Start programs in fall 2019 who were still enrolled in spring 2020; their families’ backgrounds and home environments; and the characteristics of their classrooms, centers, and programs. In addition, the report provides information on the AIAN FACES 2019 study methodology, sample, and analytic methods. The study design is the same one used for AIAN FACES 2015. For the 2015 study, the study team collaborated extensively with a workgroup made up of (1) Head Start directors from Region XI programs, (2) early childhood researchers who have worked with Native communities, (3) Mathematica researchers, and (4) federal government officials. AIAN FACES 2019 had its own workgroup, and its composition was similar to the composition of the 2015 workgroup. The AIAN FACES 2019 Workgroup gives advice on the activities involved in the study, from updating assessments and survey items to collecting and reporting on data. (author abstract)