As schools begin to reopen, 21st CCLC programs are well positioned to help students—in particular those who need extra support—take part in hands-on learning, build healthy relationships, explore a diversity of subject areas, and have a safe space to talk about their experiences and emotions. Statewide evaluations of 21st CCLC programs show the holistic set of benefits programs provide, with students in programs demonstrating academic gains, becoming more engaged in learning, and developing social and emotional skills and competencies that will help them in and out of school. This brief provides a snapshot of what the research says about 21st CCLC programs, categorizing findings to demonstrate the benefits programs provide to support the whole child. (author abstract)