This report is the fourth and final in a series entitled Self-Regulation and Toxic Stress. The first three reports in this series laid out an applied framework for self-regulation development (http://www.acf.hhs.gov/opre/resource/self-regulation-and-toxic-stress-foundations-for-understanding-self-regulation-from-an-applied-developmental-perspective, described the effects of toxic stress on self-regulation development (http://www.acf.hhs.gov/opre/resource/self-regulation-and-toxic-stress-a-review-of-ecological-biological-and-developmental-studies-of-self-regulation-and-stress), and reviewed the existing interventions for youth from birth through young adulthood (http://www.acf.hhs.gov/opre/resource/self-regulation-and-toxic-stress-report-3). The goal of this final report is to provide practical implications of this work for programs and populations relevant to the Administration for Children and Families (ACF). In this report, we first review key concepts for understanding self-regulation in context, including the relationship between stress and self-regulation. Next, we summarize key findings from our comprehensive review of self-regulation interventions, including the types of self-regulation interventions that have been evaluated, the types of populations that have been studied, and the strength of evidence for different types of outcomes for different ages. Finally and most importantly, we address how our current theory and knowledge of self-regulation may apply to different ACF programs, including those children and families living in adversity. For each developmental group examined from birth through young adulthood, specific considerations for key strategies and program elements are provided on separate pages that can be pulled out for review. (author abstract)