This brief presents six themes that emerged from a multidisciplinary literature review undertaken as part of a study on Head Start Leadership, Excellence and Data Systems (LEADS; Derrick-Mills et al. 2014). Furthermore, it explores how findings from other disciplines might apply in a Head Start setting by drawing on site visit data from the LEADS study (Derrick-Mills and Rohacek, forthcoming) and another recent project, School Readiness Goals and Head Start Program Functioning (the School Readiness study; Isaacs et al. 2015). The goal of this brief is to summarize common themes and findings that arose across both studies for the purpose of informing future research. The preliminary evidence collected through the LEADS and School Readiness studies provides a foundation from which further research questions and hypotheses might be developed in order to build a body of literature to support best data use practices in Head Start. (author abstract)